Advanced Materials and Innovative Drug Delivery (AMIDD) Lab
Research 연구 분야
View all →Local Cancer Therapy with Drug Delivery Systems
We develop advanced drug delivery systems (DDS), including multifunctional microspheres and hydrogels, engineered for localized cancer therapy.
Nanoparticle-Based Systemic Cancer Therapy
We engineer multifunctional nanoparticles tailored for precise tumor targeting in cancer therapy.
Transdermal and Topical Drug Delivery
We design advanced microneedle platforms and responsive hydrogels for effective transdermal and topical drug delivery.
About AMIDD Lab
We design disease-specific drug delivery systems and evaluate their physicochemical properties to maximize therapeutic efficacy. By fine-tuning vehicle mechanics, surface chemistry, and targeting moieties, we engineer targeted platforms tailored to unique pathological microenvironments.
Our research spans from rational synthesis of delivery systems and comprehensive characterization to evaluating cellular internalization, biological stability, and in vivo therapeutic performance. Ultimately, our goal is to overcome physiological barriers, reduce systemic toxicity, and deliver therapeutic cargos to precise disease sites.
Meet the team →News 소식
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2026. 09. 10
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2026. 06. 02
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2026. 04. 20
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2026. 03. 08
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2026. 01. 12
People
Principal Investigator
Hyun-Jong Cho (Ph.D.)
Professor
- Ph.D. Pharmaceutics, College of Pharmacy, Seoul National University
- B.S. Pharmacy, College of Pharmacy, Seoul National University
- Senior Researcher, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University
- Full-time Lecturer/Assistant Professor, College of Pharmacy, Sunchon National University
- Visiting Research Associate, Department of Bioengineering, University of California Los Angeles
- Director, Open MAP Research Institute, QuadMedicine
- Email hjcho@kangwon.ac.kr
- Office Room #316, Building #404B, College of Pharmacy, Kangwon National University, 1 Kangwondaehak-gil, Chuncheon-si, Gangwon-do, Republic of Korea
- Tel +82-33-250-6916
Research Professors / Post-doctoral Researchers 연구교수 · 박사후연구원
Song Yi Lee
Postdoctoral Researcher
B.S. Biomaterials Engineering, Kangwon National University
· Ph.D. Pharmacy, Kangwon National University
ChaeRim Hwang
Research Professor
B.S. Medical Biomaterials Engineering, Kangwon National University
· Ph.D. Pharmacy, Kangwon National University
Da In Jeong
Postdoctoral Researcher
B.S. Bio-Health Technology, Kangwon National University
· Ph.D. Pharmacy, Kangwon National University
Graduate Students 대학원생
DongHyun Shin
M.S. Student
B.S. Applied Animal Science, Kangwon National University
HyeongChan Lee
M.S. Student
B.S. Applied Animal Science, Kangwon National University
Seo Jin Jung
M.S. Student
B.S. Medical Biomaterials Engineering, Kangwon National University
Jin Jang
M.S. Student
B.S. Applied Animal Science, Kangwon National University
Yun-Ji Choi
M.S. Student
B.S. Medical Biotechnology, Kangwon National University
Sang-Yeol Park
M.S. Student
B.S. Pharmacy, Kangwon National University (Pharm.D.)
Alumni
- 2023–2025 Postdoc.Mrinmoy Karmakar — Scientist (Indian Institute of Technology Delhi)
- 2019 Ph.D.Song Yi Lee — Postdoctoral Researcher (Kangwon National University)
- 2022 Ph.D.Jung-Jin Kim — Professor (Mokpo National University)
- 2024 Ph.D.Sungyun Kim — Professor (Kangwon National University)
- 2025 Ph.D.Hao Qiaojun
- 2025 Ph.D.Da In Jeong — Postdoctoral Researcher (Kangwon National University)
- 2025 Ph.D.ChaeRim Hwang — Research Professor (Kangwon National University)
- 2026 Ph.D.Usok Hyun — Professor (Mokpo National University)
- 2016 M.S.Jeong-Jun Lee
- 2017 M.S.Jae Young Jeong — Daewon Pharm. Ltd.
- 2018 M.S.Suyeong Nam — Samil Co. Ltd.
- 2019 M.S.Ja Seong Koo — USA
- 2020 M.S.Mingyu Yang — Yuhan Chemical, Inc.
- 2020 M.S.Ji-Hye Seo — CGBio
- 2022 M.S.JiHye Park — KyungBo Pharm. Ltd.
- 2023 M.S.Hyun Jin Kim
- 2024 M.S.Yeoung Eun Choi — Hugel, Inc.
- 2025 M.S.Eun Seo Park — CellArkBio
- 2025 M.S.Ju Yeon Kim — CellArkBio
- 2026 M.S.Seo Kyoung On — CellArkBio
Research
연구 분야
Local Cancer Therapy with Drug Delivery Systems 약물전달시스템을 이용한 국소 항암 치료
We develop advanced drug delivery systems (DDS), including multifunctional microspheres and hydrogels, engineered for localized cancer therapy. By integrating smart biomaterials with precise targeting, our research aims to overcome solid tumor barriers, maximize therapeutic efficacy directly at the tumor site, and eliminate systemic toxicity for next-generation locoregional treatments.
Nanoparticle-Based Systemic Cancer Therapy 나노입자 기반 전신 항암 치료
We engineer multifunctional nanoparticles tailored for precise tumor targeting in cancer therapy. By leveraging active receptor targeting and smart stimulus-responsive mechanisms, our nanomedicine platforms efficiently penetrate tumor microenvironments. This approach ensures maximal drug accumulation directly within cancer cells while minimizing off-target side effects for safer and high-efficacy oncology treatments.
Transdermal and Topical Drug Delivery 경피 및 국소 약물전달
We design advanced microneedle platforms and responsive hydrogels for effective transdermal and topical drug delivery. By bypassing skin barriers with minimal invasiveness, our smart biomaterials enable sustained, localized therapeutic release. This strategy dramatically enhances drug bioavailability directly at target tissues while improving patient compliance.
Non-Invasive Mucosal & Pulmonary Drug Delivery 비침습적 점막 및 폐 약물전달
We develop innovative non-invasive delivery platforms targeting intranasal, oromucosal, and pulmonary routes. By engineering mucosal-adhesive formulations and aerosolizable nanocarriers, our systems overcome epithelial barriers to achieve rapid mucosal absorption and direct lung targeting, enabling highly efficient, non-systemic therapeutics for systemic and respiratory disorders.
Facilities & Instruments 주요 장비
장비명 01
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장비명 02
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Publications
연구 논문
2026
Cyclic mechanical stretch suppresses intrinsic apoptosis in high metastatic melanoma.
Mater Today Bio, 2026, 38, 103132.
Bidirectional mechanical stimulation enables biomechanical coupling and functional maturation in arterial microphysiological systems.
Adv Healthc Mater, 2026, 15(12), e05915.
Limosilactobacillus reuteri alleviates psoriasis via aryl hydrocarbon receptor-mediated regulation of Interkeukin-17A.
Int Immunopharmacol, 2026, 172, 116194.
2025
Pharmacokinetic and bioequivalence evaluation of two sitagliptin tablets with different salts in healthy subjects.
Clin Pharmacol Drug Develop, 2025, 14(10), 781-786.
Multifunctional bioactive dual-layered nanofibrous matrix for effective breast cancer therapy and enhanced wound healing.
Small, 2025, (*co-corresponder) 21(31), 2500717.
Baricitinib-loaded separable microneedle array patch (S-MAP) based on hyaluronic acid for alopecia areata therapy.
Carbohydr Polym, 2025, 364, 123789 (*co-corresponder).
Cellulose nanocrystal-annealed hydrogel system for local chemo-metabolic therapy of melanoma.
J Control Release, 2025, 377, 324-338.
2024
Intravascular casting radiopaque hydrogel systems for transarterial chemo/cascade catalytic/embolization therapy of hepatocellular carcinoma.
Small, 2024, 20(46), 2400287 (*co-corresponder).
Investigating the immune-stimulating potential of β-glucan from aureobasidium pullulans in cancer immunotherapy.
Biomol Ther, 2024, 32(5), 556‒567.
Injectable hydrogel systems for local cancer therapy.
J Pharm Investig, 2024, 54(5), 555-591 (*co-corresponder).
Hydrogel design to overcome thermal resistance and ROS detoxification in photothermal and photodynamic therapy of cancer.
J Control Release, 2024, 366, 142-159.
2023
Alum-tuned hyaluronic acid-based hydrogel with immune checkpoint inhibition for immunophoto therapy of cancer.
J Control Release, 2023, 362, 1-18 (*co-corresponder).
Nanorod/nanodisk-integrated liquid crystalline systems for starvation, chemodynamic, and photothermal therapy of cancer.
Bioeng Trans Med, 2023, 8(5) e10470.
Cuproptosis-inducible chemotherapeutic/cascade catalytic reactor system for combating with breast cancer.
Small, 2023, 19(35), 2301402.
Manganese sulfate nanocomposites fabricated by hot-melt ex-trusion for chemodynamic therapy of colorectal cancer.
Pharmaceutics, 2023, 15, 1831.
Flash dissolving nanofiber membranes for chemo/cascade chemodynamic therapy of oral cancer.
Mater Design, 2023, 231, 112063.
Tunable hybrid hydrogels with multicellular spheroids for modeling desmoplastic pancreatic cancer.
Bioact Mater, 2023, 25, 360-373.
2022
Perfluorooctylbromide-loaded fucoidan-chlorin e6 nanoparticles for tumor-targeted photodynamic therapy.
Int J Biol Macromol, 2022, 223(Part A), 77-86.
Donepezil hydrochloride-reinforced cellulose nanocrystal-aggregated gel structure for long-acting drug delivery.
Carbohydr Polym, 2022, 296, 119887.
Ferrocene and glucose oxidase-installed multifunctional hydrogel reactors for local cancer therapy.
J Control Release, 2022, 349, 617-633.
Extended transit compartment model to describe tumor delay using Coxian distribution.
Sci Rep, 2022, 12, 10086.
Co-electrospun silk fibroin and gelatin methacryloyl sheet seeded with mesenchymal stem cells for tendon regeneration.
Small, 2022, 18(21), 2107714.
pH-Responsive doxorubicin delivery using shear-thinning biomaterials for localized melanoma treatment.
Nanoscale, 2022, 14(2), 350-360.
Engineering liver microtissues to study the fusion of HepG2 with mesenchymal stem cells and invasive potential of fused cells.
Biofabrication, 2022, 14(1), 014104.
2021
Fast dissolving nanofiber mat for the local antimicrobial application of roxithromycin in oral cavity.
Mater Sci Eng C Mater Biol Appl, 2021, 131, 112537 (*co-corresponder).
Gas generating microspheres for immediate release of Hsp90 inhibitor aiming at postembolization hypoxia in transarterial chemoembolization therapy of hepatocellular carcinoma.
Int J Pharm, 2021, 607, 120988 (*co-corresponder).
Effects of hot-melt extruded nano-copper as an alternative for the pharmacological dose of copper sulfate in weanling pigs.
Biol Trace Elem Res, 2021, 199(8), 2925-2935.
Polypseudorotaxane and polydopamine linkage-based hyaluronic acid hydrogel network with a single syringe injection for sustained drug delivery.
Carbohydr Polym, 2021, 266, 118104.
Biofabrication of endothelial cell, dermal fibroblast, and multilayered keratinocyte layers for skin tissue engineering.
Biofabrication, 2021, 13(3), 035030.
Bioengineered multicellular liver microtissues for modeling advanced hepatic fibrosis driven through non-alcoholic fatty liver disease.
Small, 2021, 17(14), 2007425 (+co-first). [cover article]
Serially pH-modulated hydrogels based on boronate ester and polydopamine linkages for local cancer therapy.
ACS Appl Mater Interfaces, 2021, 13(2), 2189-2203.
Hyaluronidase inhibitor-incorporated crosslinked hyaluronic acid hydrogels for subcutaneous injection.
Pharmaceutics, 2021, 13, 170 (*co-corresponder).
Nano-sized Zinc in Broiler Chickens: Effects on Growth Performance, Zinc Concentration in Organs, and Intestinal Morphology.
J Poult Sci, 2021, 58(1), 21-29.
2020
Rhodamine conjugated gelatin methacryloyl nanoparticles for stable cell imaging.
ACS Appl Bio Mater, 2020, 3(10), 6908-6918.
Thrombolytic agents: Nanocarriers in controlled release.
Small, 2020, 16(40), 2001647.
Monopotassium phosphate-reinforced in situ forming injectable hyaluronic acid hydrogels for subcutaneous injection.
Int J Biol Macromol, 2020, 163, 2134‒2144.
Preparation and characterization of sorafenib-loaded microprecipitated bulk powder for enhancing oral bioavailability.
Int J Pharm, 2020, 589, 119836.
Docetaxel-loaded chitosan-cholesterol conjugate-based self-assembled nanoparticles for overcoming multidrug resistance in cancer cells.
Pharmaceutics, 2020, 12(9), 783 (*co-corresponder).
Selenium and dopamine-crosslinked hyaluronic acid hydrogel for chemophotothermal cancer therapy.
J Control Release, 2020, 324, 750-764.
Multi-layered cellulose nanocrystal system for CD44 receptor-positive tumor-targeted anticancer drug delivery.
Int J Biol Macromol, 2020, 162, 798-809.
Mechanical cues regulating proangiogenic potential of human mesenchymal stem cells through YAP-mediated mechanosensing.
Small, 2020, 16(25), 2001837. [cover article]
Hot melt extruded-based nano zinc as an alternative to the pharmacological dose of ZnO in weanling piglets.
Asian Austral J Anim Sci, 2020, 33(6), 992-1001.
Ferrous sulfate-directed dual-cross-linked hyaluronic acid hydrogels with long-term delivery of donepezil.
Int J Pharm, 2020, 582, 119309.
Biological evaluation of hot-melt extruded nano-selenium and the role of selenium on the expression profiles of selenium-dependent antioxidant enzymes in chickens.
Biol Trace Elem Res., 2020, 194(2), 536-544.
Supplemental hot melt extruded nano-selenium increases expression profiles of antioxidant enzymes in the livers and spleens of weanling pigs.
Anim Feed Sci Tech, 2020, 262, 114381.
Blood component ridable and CD44 receptor targetable nanoparticles based on a maleimide-functionalized chondroitin sulfate derivative.
Carbohydr Polym, 2020, 230, 115568 (*co-corresponder).
Recent advances in physiologically based pharmacokinetic and pharmacodynamics models for anticancer nanomedicines.
Arch Pharm Res, 2020, 43(1), 80-99 (*co-corresponder).
2019
In vitro human liver model of nonalcoholic steatohepatitis by co-culturing hepatocytes, endothelial cells, and Kupffer cells.
Adv Healthc Mater, 2019, 8(24), 1901379. [cover article]
Effects of hot melt extrusion processed nano-iron on growth performance, blood composition, and iron bioavailability in weanling pigs.
J Anim Sci Technol, 2019, 61(4), 216-224.
Esterase-sensitive cleavable histone deacetylase inhibitor-coupled hyaluronic acid nanoparticles for boosting anticancer activities against lung adenocarcinoma.
Biomater Sci, 2019, 7(11), 4624-4635 (*co-corresponder).
Recent progress in the development of poly(lactic-co-glycolic acid)-based nanostructures for cancer imaging and therapy.
Pharmaceutics, 2019, 11(6), 280 (*co-corresponder). [cover article]
Application of temporary agglomeration of chitosan-coated nanoparticles for the treatment of lung metastasis of melanoma.
J Colloid Interface Sci, 2019, 544, 266-275.
Mitochondria targeting and destabilizing hyaluronic acid derivative-based nanoparticles for the delivery of lapatinib to triple-negative breast cancer.
Biomacromolecules, 2019, 20(2), 835-845.
Polyethylene glycol-decorated doxorubicin/carboxymethyl chitosan/gold nanocomplex for reducing drug efflux in cancer cells and extending circulation in blood stream.
Int J Biol Macromol, 2019, 125, 61-71 (equally contributed).
Development of iron(II) sulfate nanoparticles produced by hot-melt extrusion and their therapeutic potentials for colon cancer.
Int J Pharm, 2019, 558, 388-395.
Mitoxantrone-loaded PEGylated gold nanocomplexes for cancer therapy.
J Nanosci Nanotechnol, 2019, 19, 687-690.
2018
Physostigmine-loaded liposomes for extended prophylaxis against nerve agent poisoning.
Int J Pharm, 2018, 553(1-2) 467-473.
Tumor targeting and lipid rafts disrupting hyaluronic acid-cyclodextrin-based nanoassembled structure for cancer therapy.
ACS Appl Mater Interfaces, 2018, 10(43) 36628-36640.
Preparation of cupric sulfate-based self-emulsifiable nanocomposites and their application to the photothermal therapy of colon adenocarcinoma.
Biochem Biophys Res Commun, 2018, 503(4), 2471-2477.
Therapeutic efficacies of Artemisia capillaris extract cream formulation in imiquimod-induced psoriasis models.
Evid Based Complement Alternat Med, 2018, 2018, 3610494.
Simultaneous determination and stability test of two phthalic anhydride derivatives, Senkyunolide A and Z-Ligustilide, in the water extract of Cnidium Rhizome from different geographical regions and species using HPLC-UVD analysis: Simultaneous determination and stability test of Senkyunolide A and Z-Ligustilide.
. Bull Kor Chem Soc, 2018, 39(6), 784-788.
Hyaluronic acid/doxorubicin nanoassembly-releasing microspheres for the transarterial chemoembolization of a liver tumor.
Drug Deliv, 2018, 25(1), 1472-1483 (*co-corresponder).
Development of resveratrol-loaded herbal extract-based nanocomposites and their application to the therapy of ovarian cancer.
Nanomaterials, 2018, 8(6), 384.
Berberine and zinc oxide-based nanoparticles for the chemo-photothermal therapy of lung adenocarcinoma.
Biochem Biophys Res Commun, 2018, 501(3), 765-770.
Antiproliferation of keratinocytes and alleviation of psoriasis by the ethanol extract of Artemisia capillaris.
Phytother Res, 2018, 32(5), 923-932.
An α-tocopheryl succinate enzyme-based nanoassembly for cancer imaging and therapy.
Drug Deliv, 2018, 25(1), 738-749.
Polydopamine-coated nanocomposites of Angelica gigas Nakai extract and their therapeutic potential for triple-negative breast cancer cells.
Colloids Surf B Biointerfaces, 2018, 165, 74-82.
2017
Doxorubicin-Wrapped Zinc Oxide Nanoclusters for the Therapy of Colorectal Adenocarcinoma.
Nanomaterials, 2017, 7(11), 354.
Poly((D,L)lactic-glycolic)acid-star glucose nanoparticles for glucose transporter and hypoglycemia-mediated tumor targeting.
Int J Nanomedicine, 2017, 12, 7453-7467 (*co-corresponder).
Fabrication of polymer matrix-free nanocomposites based on Angelica gigas Nakai extract and their application to breast cancer therapy.
Colloids Surf B Biointerfaces, 2017, 159, 781-790.
Novel reverse electrodialysis-driven iontophoretic system for topical and transdermal delivery of poorly permeable therapeutic agents.
Drug Deliv, 2017, 24(1), 1204-1215.
Phloretin-loaded fast dissolving nanofibers for the locoregional therapy of oral squamous cell carcinoma.
J Colloid Interface Sci, 2017, 508, 112-120.
Mussel-inspired hyaluronic acid derivative nanostructures for improved tumor targeting and penetration.
ACS Appl Mater Interfaces, 2017, 9(27) 22308-22320.
Chemosensitizing indomethacin-conjugated chitosan oligosaccharide nanoparticles for tumor-targeted drug delivery.
Acta Biomater, 2017, 57, 262-273 (*co-corresponder).
Angelica gigas Nakai extract-loaded fast-dissolving nanofiber based on poly(vinyl alcohol) and Soluplus for oral cancer therapy.
Int J Pharm, 2017, 526(1-2), 225-234.
Boronic acid-tethered amphiphilic hyaluronic acid derivative-based nanoassemblies for tumor targeting and penetration.
Acta Biomater, 2017, 53, 414-426 (*co-corresponder).
Sorafenib and 2,3,5-triiodobenzoic acid-loaded imageable microspheres for transarterial embolization of a liver tumor.
Sci Rep, 2017, 7, 554 (*co-corresponder).
Cefdinir solid dispersion composed of hydrophilic polymers with enhanced solubility, dissolution, and bioavailability in rats.
Molecules, 2017, 22(2), 280 (*equally contributed).
Development of polyethylene glycol-conjugated chitosan oligosaccharide derivative-stabilized gold nanoassamblies.
J Nanosci Nanotechnol, 2017, 17(4), 2370-2374 (*co-corresponder).
Capmul MCM/Solutol HS15-based microemulsion for enhanced oral bioavailability of rebamipide.
J Nanosci Nanotechnol, 2017, 17(4), 2340-2344.
Dopamine-conjugated poly(lactic-co-glycolic acid) nanoparticles for protein > delivery to macrophages.
J Colloid Interface Sci, 2017, 490, 391-400.
2016
Anticancer efficacy of photodynamic therapy with lung cancer targeted nanoparticles.
JoVE, 2016, 118, e54865.
Development of HPLC method for the determination of buspirone in rat plasma using fluorescence detection and its application to a pharmacokinetic study.
Chem Pharm Bull, 2016, 64 (11), 1582-1588.
Enhanced cellular uptake and pharmacokinetic characteristics of doxorubicin-valine amide prodrug.
Molecules, 2016, 21 (10), 1272. (*co-corresponder).
Nanocomposites based on Soluplus and Angelica gigas Nakai extract fabricated by an electrohydrodynamic method for oral administration.
J Colloid Interface Sci, 2016, 484, 146-154.
Amine-functionalized poly(lactic-co-glycolic acid) nanoparticles for improved cellular uptake and tumor penetration.
Colloids Surf B Biointerfaces, 2016, 148, 85-94.
Transient aggregation of chitosan-modified poly(D,L-lactic-co-glycolic) acid nanoparticles in the blood stream and improved lung targeting efficiency.
J Colloid Interface Sci, 2016, 480, 102-108 (*co-corresponder).
Effects of nonalcoholic fatty liver disease on hepatic CYP2B1 and in vivo bupropion disposition in rats fed a high-fat or methionine/choline-deficient diet.
J Agric Food Chem, 2016, 64, 5598-5606.
Dual CD44 and folate receptor-targeted nanoparticles for cancer diagnosis and anticancer drug delivery.
J Control Release, 2016, 236, 38-46 (*co-corresponder).
Cholesterol-modified poly(lactide-co-glycolide) nanoparticles for tumor-targeted drug delivery.
Int J Pharm, 2016, 509 (1-2), 483-491.
Polyethylene glycol-conjugated chondroitin sulfate A derivative nanoparticles for tumor-targeted delivery of anticancer drugs.
Carbohydr Polym, 2016, 151, 68-77 (*co-corresponder).
Electrosprayed nanocomposites based on hyaluronic acid derivative and Soluplus for tumor-targeted drug delivery.
Colloids Surf B Biointerfaces, 2016, 145, 267-274.
Development of intranasal nanovehicles of itraconazole and their immunological activities for the therapy of rhinovirus infection.
Colloids Surf B Biointerfaces, 2016, 143, 336-341 (*co-corresponder).
Hypocrellin B and paclitaxel-encapsulated hyaluronic acid-ceramide nanoparticles for targeted photodynamic therapy in lung cancer.
J Photochem Photobiol B, 2016, 158, 113-121.
Iodinated hyaluronic acid oligomer-based nanoassemblies for tumor-targeted drug delivery and cancer imaging.
Biomaterials, 2016, 85, 218-231. (*co-corresponder).
Ready-to-use colloidal adjuvant systems for intranasal immunization.
J Colloid Interface Sci, 2016, 467, 121-128 (*co-corresponder).
Omega-3 fatty acids incorporated colloidal systems for the delivery of Angelica gigas Nakai extract.
Colloids Surf B Biointerfaces, 2016, 140, 239-245.
Metabolic interactions of magnolol with cytochrome P450 enzymes: uncompetitive inhibition of CYP1A and competitive inhibition of CYP2C.
Drug Dev Ind Pharm, 2016, 42(2), 263-269.
Poly(lactic-co-glycolic) acid/Solutol HS15-based nanoparticles for docetaxel delivery.
J Nanosci Nanotechnol, 2016, 16(2), 1433-1436.
Ceramide and N,N,N-trimethylphytosphingosine-iodide (TMP-I)-based lipid nanoparticles for cancer therapy.
Pharm Res, 2016, 33(1), 206-216 (*co-corresponder).
2015
Modulation of cytochrome P450 activity by curcumin and its pharmacokinetic consequences in rats.
Pharmacogn Mag, 2015, 11(44), 580-584. (*co-corresponder).
Improvement of antiproliferative activity of Angelica gigas Nakai by solid dispersion formation via hot-melt extrusion and induction of cell cycle arrest and apoptosis in HeLa cells.
Biosci Biotechnol Biochem, 2015, 79(10), 635-1643.
Modulation of cytochrome P450 activity by 18β-glycyrrhetic acid and its consequence on buspirone pharmacokinetics in rats.
Phytother Res, 2015, 29(8), 1188-1194.
Bile acid-conjugated chondroitin sulfate A-based nanoparticles for tumor-targeted anticancer drug delivery.
Eur J Pharm Biopharm, 2015, 94, 532-541. (*co-corresponder).
Phenylboronic acid-decorated chondroitin sulfate A-based theranostic nanoparticles for enhanced tumor targeting and penetration.
Adv Funct Mater, 2015, 25 (24), 3705-3717. (*co-corresponder)
Doxorubicin-loaded poly(lactic-co-glycolic acid) microspheres prepared using the solid-in-oil-in-water method for the transarterial chemoembolization of a liver tumor.
Colloids Surf B Biointerfaces, 2015, 132, 305-312. (*co-corresponder)
Soluplus/TPGS-based solid dispersions prepared by hot-melt extrusion equipped with twin screw systems for enhancing oral bioavailability of valsartan.
Drug Des Develop Ther, 2015, 9, 2745-2756.
Angelica gigas Nakai and Soluplus-based solid formulations prepared by hot-melting extrusion: oral absorption enhancing and memory ameliorating effects.
PLoS One, 2015, 10(4):30124447 (*co-corresponder).
Poly(D,L-lactic acid)-glycerol-based nanoparticles for curcumin delivery.
Int J Pharm, 2015, 488(1-2), 70-77.
Hyaluronic acid-ceramide (HACE)-based liposomes for targeted gene delivery to CD44-positive cancer cells.
Bull Kor Chem Soc, 2015, 36(3), 874-881.
Carbopol-incorporated thermoreversible gel for intranasal drug delivery.
Molecules, 2015, 20(3), 4124-4135.
Pharmacokinetic interaction of herbs with cytochrome P450 and P-glycoprotein.
Evid Based Complement Alternat Med, 2015, 2015, ID736431.
2014
Comparison of drug release and pharmacokinetics after transarterial chemoembolization using diverse lipiodol emulsions and drug-eluting beads.
PLoS One, 2014, 9(12), e115898 (*equally contributed).
Elevated endoplasmic reticulum stress reinforced immunosuppression in the tumor microenvironment via myeloid-derived suppressor cells.
Oncotarget, 2014, 5(23), 12331-12345.
Chitosan-based hybrid nanocomplex for siRNA delivery and its application for cancer therapy.
Pharm Res, 2014, 31(12), 3323-3334.
Nanocomplexes based on amphiphilic hyaluronic acid derivative and polyethylene glycol-lipid for ginsenoside Rg3 delivery.
J Pharm Sci, 2014, 103(10), 3254-3262 (*co-corresponder).
Development of poly(lactic-co-glycolic) acid nanoparticles-embedded hyaluronic acid-ceramide-based nanostructure for tumor-targeted drug delivery.
Int J Pharm, 2014, 473(1-2), 426-433 (*co-corresponder).
Interconnected hyaluronic acid derivative-based nanoparticles for anticancer drug delivery.
Colloids Surf B Biointerfaces, 2014, 121, 380-387 (* equally contributed).
In vitro-in vivo extrapolation (IVIVE) for predicting human intestinal absorption and first-pass elimination of drugs: principles and applications.
Drug Dev Ind Pharm, 2014, 40(8), 989-998.
Poly(styrene)-b-poly(DL-lactide) copolymer-based nanoparticles for docetaxel delivery.
Int J Nanomedicine, 2014, 9, 2803-2813 (*co-corresponder).
A new injectable liquid crystal system for one month delivery of leuprolide.
J Control Release, 2014, 185, 62-70.
Budesonide/cyclodextrin-loaded lyophilized microparticles for intranasal application.
Drug Dev Ind Pharm, 2014, 40(6), 743-748 (*co-corresponder).
In vitro and in vivo evaluation of puerarin on hepatic cytochrome P450-mediated drug metabolism.
Planta Med, 2014, 80(7), 561-567.
Polyethylene glycol-modified arachidyl chitosan-based nanoparticles for prolonged blood circulation of doxorubicin.
Int J Pharm, 2014, 464(1-2), 127-134 (*co-corresponder).
Emulsion-based colloidal nanosystems for oral delivery of doxorubicin: Improved intestinal paracellular absorption and alleviated cardiotoxicity.
Int J Pharm, 2014, 464(1-2), 117-126.
Surface-modified solid lipid nanoparticles for oral delivery of docetaxel: enhanced intestinal absorption and lymphatic uptake.
Int J Nanomedicine, 2014, 9, 495-504.
Chondroitin sulfate-capped gold nanoparticles for the oral delivery of insulin.
Int J Biol Macromol, 2014, 63, 15-20.
Hyaluronic acid derivative-coated nanohybrid liposomes for cancer diagnosis and drug delivery.
J Control Release, 2014, 174, 98-108 (*equally contributed).
2013
Porous hyaluronic acid/sodium alginate composite scaffolds for human adipose-derived stem cells delivery.
Int J Biol Macromol, 2013, 61, 175-181.
The limited intestinal absorption via paracellular pathway is responsible for the low oral bioavailability of doxorubicin.
Xenobiotica, 2013, 43(7), 579-591.
Self-assembled magnetic resonance imaging nanoprobes based on arachidyl chitosan for cancer diagnosis.
Colloids Surf B Biointerfaces, 2013, 109, 280-286. (*equally contributed)
Chitosan oligosaccharide-arachidic acid-based nanoparticles for anti-cancer drug delivery.
Int J Pharm, 2013, 441(1-2), 373-380. (*equally contributed)
Anti-inflammatory property of anthraquinones and their relationship with the regulation of P-glycoprotein function and expression.
Eur J Pharm Sci, 2013, 48(1-2), 272-281.
A novel lipid nanoemulsion system for improved permeation of granisetron.
Colloids Surf B Biointerfaces, 2013, 101, 475-480. (*co-corresponder)
2012
Hyaluronic acid derivative-based self-assembled nanoparticles for the treatment of melanoma.
Pharm Res, 2012, 29(12), 3443-3454. (* co-corresponder)
Saturable sinusoidal uptake is rate-determining process in hepatic elimination of docetaxel in rats.
Xenobiotica, 2012, 42(11), 1110-1119.
Hyaluronic acid-ceramide-based optical/MR dual imaging nanoprobe for cancer diagnosis.
J Control Release, 2012, 162(1), 111-118.
Inclusion complex effect on the bioavailability of clotrimazole from poloxamer-based solid suppository.
Arch Pharm Res, 2012, 35(7), 1169-1175.
Cytotoxic terpenoids from Juglans sinensis leaves and twigs.
Bioorg Med Chem Lett, 2012, 22(5), 2079-2083.
Cross-linked hyaluronic acid--based flexible cell delivery system: Application for chondrogenic differentiation.
Colloids Surf B Biointerfaces, 2012, 91, 106-113.
Development of udenafil-loaded microemulsions for intranasal delivery: in vitro and in vivo evaluations.
Int J Pharm, 2012, 423(2), 153-160. (*equally contributed)
Polyethylene glycol-conjugated hyaluronic acid-ceramide self-assembled nanoparticles for targeted delivery of doxorubicin.
Biomaterials, 2012, 33(4), 1190-1200.
2011
Interpenetrating polymer network (IPN) scaffolds of sodium hyaluronate and sodium alginate for chondrocyte culture.
Colloids Surf B Biointerfaces, 2011, 88(2), 711-716.
Preparation and characterization of MRI-active gadolinium nanocomposite particles for neutron capture therapy.
J Mater Chem, 2011, 21, 15486-15493.
Proliferation and chondrogenic differentiation of human adipose-derived mesenchymal stem cells in porous hyaluronic acid scaffold.
J Biosci Bioeng, 2011, 112(4), 402-408.
Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel.
Biomaterials, 2011, 32(29), 7181-7190.
Rapid and sensitive determination of udenafil in plasma by LC-MS/MS for intranasal pharmacokinetic study in rats.
Chem Pharm Bull, 2011, 59(9), 1083-1088.
Poloxamer/cyclodextrin/chitosan-based thermoreversible gel for intranasal delivery of fexofenadine hydrochloride.
J Pharm Sci, 2011, 100(2), 681-691.
2010
Preparation and evaluation of fexofenadine microemulsions for intranasal delivery.
Int J Pharm, 2010, 395(1-2), 309-316.
Preparation and evaluation of spray-dried hyaluronic acid microspheres for intranasal delivery of fexofenadine hydrochloride.
Eur J Pharm Sci, 2010, 40(1), 9-15.
2007
Air-liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport studies.
J Pharm Sci, 2007, 96(2), 341-350.
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연구실 활동